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Insulin Sensitivity as a Key Mediator of Growth Hormone Actions on Longevity.
- Source :
- Journals of Gerontology Series A: Biological Sciences & Medical Sciences; May2009, Vol. 64A Issue 5, p516-521, 6p, 4 Graphs
- Publication Year :
- 2009
-
Abstract
- Reduced insulin sensitivity and glucose intolerance have been long suspected of having important involvement in aging. Here we report that in studies of calorie restriction (CR) effects in mutant (Propl<superscript>df</superscript> and growth hormone receptor knockout [GHIRKO]) and normal mice, insulin sensitivity was strongly associated with longevity. Of particular interest was enhancement of the already increased insulin sensitivity in CR df/df mice in which longevity was also further extended and the lack of changes in insulin sensitivity in calorically restricted GHRKO mice in which there was no further increase in average life span. We suggest that enhanced insulin sensitivity, in conjunction with reduced insulin levels, may represent an important (although almost certainly not exclusive) mechanism of increased longevity in hypopituitary, growth hormone (GH)-resistant, and calorie-restricted animals. We also report that the effects of GH treatment on insulin sensitivity may be limited to the period of OH administration. [ABSTRACT FROM AUTHOR]
- Subjects :
- SOMATOTROPIN
INSULIN therapy
LONGEVITY
LOW-calorie diet
LABORATORY mice
Subjects
Details
- Language :
- English
- ISSN :
- 10795006
- Volume :
- 64A
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journals of Gerontology Series A: Biological Sciences & Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 41139773
- Full Text :
- https://doi.org/10.1093/gerona/glp024