Aripiprazole monotherapy in acute mania: 12-week randomised placebo- and haloperidol-controlled study.

<bold>Background: </bold>Well-tolerated and effective therapies for bipolar mania are required.<bold>Aims: </bold>To evaluate the efficacy and tolerability of aripiprazole as acute and maintenance of effect therapy in patients with bipolar I disorder experiencing manic or mixed episodes.<bold>Method: </bold>Patients were randomised to double-blind aripiprazole (15 or 30 mg/day; n=167), placebo (n=153) or haloperidol (5-15 mg/day, n=165) for 3 weeks (trial registration NCT00097266). Aripiprazole- and haloperidol-treated patients remained on masked treatment for 9 additional weeks.<bold>Results: </bold>Mean change in Young Mania Rating Scale Total score (primary end-point) at week 3 was significantly greater with aripiprazole (-12.0; P<0.05) and haloperidol (-12.8; P<0.01) than with placebo (-9.7). Improvements were maintained to week 12 for aripiprazole (-17.2) and haloperidol (-17.8). Aripiprazole was well tolerated. Extrapyramidal adverse events were more frequent with haloperidol than aripiprazole (53.3% v. 23.5%).<bold>Conclusions: </bold>Clinical improvements with aripiprazole were sustained to week 12. Aripiprazole was generally well tolerated. [ABSTRACT FROM AUTHOR]