Bosentan Decreases Pulmonary Vascular Resistance and Improves Exercise Capacity in Acute Hypoxia.

The article discusses the study which examines the contribution of pulmonary vascular resistance (PVR) to decrease the capacity in hypoxic healthy respondents. The study used ergometer cardiopulmonary exercise test and echocardiographic estimation of pulmonary artery pressure and cardiac to calculate total PVR for healthy volunteers in normoxia and hypoxic breathing. It found that hypoxic pulmonary hypertension restricts exercise capacity in healthy subjects and prevent therapy.