GM1 Delivery to the CSF Via the Olfactory Pathway.

The objective of this study was to determine if monosialogan- glioside (GM1) can be delivered to the brain via the olfactory neural pathway (o.p.). GM1 solution was administered via the o.p. and i.v. route to rats, after which cerebrospinal fluid (CSF) was collected. Two other formulations of GM1, GM1-lipid nanospheres (GM1-LNS) and GM1-DOTAP (a positively charged lipid) complex, were also tested. The results showed that GM1 can be delivered to the brain via the o.p. However, GM1-LNS administered i.v. delivered the highest concentrations of GM1 to the CSF; this formulation may potentially be useful in treatment of spinal cord injury. [ABSTRACT FROM AUTHOR]