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ccbe1 is required for embryonic lymphangiogenesis and venous sprouting.

Authors :
Hogan, Benjamin M.
Bos, Frank L.
Bussmann, Jeroen
Witte, Merlijn
Chi, Neil C.
Duckers, Henricus J.
Schulte-Merker, Stefan
Source :
Nature Genetics; Apr2009, Vol. 41 Issue 4, p396-398, 3p, 2 Color Photographs
Publication Year :
2009

Abstract

Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10614036
Volume :
41
Issue :
4
Database :
Complementary Index
Journal :
Nature Genetics
Publication Type :
Academic Journal
Accession number :
37211014
Full Text :
https://doi.org/10.1038/ng.321