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Gene-Environment Interaction in Genome-Wide Association Studies.
- Source :
- American Journal of Epidemiology; Jan2009, Vol. 169 Issue 2, p219-219, 1p
- Publication Year :
- 2009
-
Abstract
- It is a commonly held belief that most complex diseases (e.g., diabetes, asthma, cancer) are affected in part by interactions between genes and environmental factors. However, investigators conducting genome-wide association studies typically test for only the marginal effects of each genetic marker on disease. In this paper, the authors propose an efficient and easily implemented 2-step analysis of genome-wide association study data aimed at identifying genes involved in a gene-environment interaction. The procedure complements screening for marginal genetic effects and thus has the potential to uncover new genetic signals that have not been identified previously. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00029262
- Volume :
- 169
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 36985782