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Expression of the urokinase plasminogen activator receptor (uPAR) and its ligand (uPA) in brain tissues of human immunodeficiency virus patients with opportunistic cerebral diseases.
- Source :
- Journal of NeuroVirology; Feb2009, Vol. 15 Issue 1, p99-107, 9p, 2 Color Photographs, 1 Chart
- Publication Year :
- 2009
-
Abstract
- The urokinase plasminogen activator receptor (uPAR) and its ligand (uPA) play an important role in cell migration and extracellular proteolysis. We previously described uPAR/uPA overexpression in the cerebrospinal fluid (CSF) and brain tissues of patients with human immunodeficiency virus (HIV)-related cerebral diseases. In this study, we examined uPAR/uPA expression by immunohistochemistry (IHC) in brains of HIV patients with opportunistic cerebral lesions and in HIV-positive/negative controls. uPAR was found in macrophages/microglia with the highest levels in cytomegalovirus (CMV) encephalitis, toxoplasmosis, and lymphomas; in cryptococcosis and progressive multifocal leukoencephalopathy (PML) cases, only a few positive cells were found and no positivity was observed in controls. uPA expression was demonstrated only in a few macrophages/microglia and lymphocytes in all the cases and HIV-positive controls without different pattern of distribution; no uPA immunostaining was found in cryptococcosis and HIV-negative controls. The higher expression of uPAR/uPA in most of the opportunistic cerebral lesions supports their role in these diseases, suggesting their contribution to tissue injury. [ABSTRACT FROM AUTHOR]
- Subjects :
- UROKINASE
PLASMINOGEN activators
PLASMINOKINASE
HIV
CEREBROSPINAL fluid
Subjects
Details
- Language :
- English
- ISSN :
- 13550284
- Volume :
- 15
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of NeuroVirology
- Publication Type :
- Academic Journal
- Accession number :
- 36798224
- Full Text :
- https://doi.org/10.1080/13550280802400692