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Urinary tract infections and reduced risk of bladder cancer in Los Angeles.
- Source :
- British Journal of Cancer; 3/10/2009, Vol. 100 Issue 5, p834-839, 6p, 4 Charts
- Publication Year :
- 2009
-
Abstract
- We investigated the association between urinary tract infections (UTIs) and transitional cell carcinoma of the bladder in a population-based case-control study in Los Angeles covering 1586 cases and age-, gender-, and race-matched neighbourhood controls. A history of bladder infection was associated with a reduced risk of bladder cancer among women (odds ratio (OR), 0.66; 95% confidence interval (CI), 0.46-0.96). No effect was found in men, perhaps due to power limitations. A greater reduction in bladder cancer risk was observed among women with multiple infections (OR, 0.37; 95% CI, 0.18-0.78). Exclusion of subjects with a history of diabetes, kidney or bladder stones did not change the inverse association. A history of kidney infections was not associated with bladder cancer risk, but there was a weak association between a history of other UTIs and slightly increased risk among men. Our results suggest that a history of bladder infection is associated with a reduced risk of bladder cancer among women. Cytotoxicity from antibiotics commonly used to treat bladder infections is proposed as one possible explanation. [ABSTRACT FROM AUTHOR]
- Subjects :
- BLADDER cancer
URINARY tract infections
CANCER risk factors
ANTIBIOTICS
Subjects
Details
- Language :
- English
- ISSN :
- 00070920
- Volume :
- 100
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- British Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 36792711
- Full Text :
- https://doi.org/10.1038/sj.bjc.6604889