Oxidizability of Atherogenic Low-Density Lipoprotein Subspecies in Severe Familial Hypercholesterolemia: Impact of Long-Term Low-Density Lipoprotein Apheresis.

The article presents a study which examined the role of oxidative modification of low-density lipoprotein (LDL) in the pathophysiology of artherosclerosis and assessed LDL-apheresis, an efficient treatment of homozygous familial hypercholesterolemia (FH). The study evaluated the impact of long-term LDL apheresis treatment on atherogenicity of the major LDL subclasses. Also discussed is the chemical analysis of LDL subfractions.