N-Methyl-N-Nitrosourea-Induced Odontogenic Neoplasms in Rats.

The article reports on a study that investigated the optimal pH effect for N-methyl-N-nitrosourea-induced odontogenic neoplasms in rats. The conclusion is that with a pH of four the gingival epithelium has the characteristics of dental lamina and appears to be the source of keratocyts, ghost cells, dentinoid masses, and denticles. Radiographs show a neoplasm or expansile lesion in the mandible and dentinoid tissue in the periodontal ligament. Research methods include 26 Wistar female rats that were separated into three groups.