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Effect of Progestins on Androgen Δ4-3-Ketosteroid-5α-A-Ring Reductase System in Rat Oral Mucosa.
- Source :
- Journal of Dental Research; Mar1978, Vol. 57 Issue 3, p511-519, 9p, 1 Black and White Photograph, 2 Charts, 3 Graphs
- Publication Year :
- 1978
-
Abstract
- Rat oral mucosa microsomal Δ<superscript>4</superscript>-3-ketosteroid-5α-A-ring reductase enzyme system, reducing testosterone and 4-androstenedione, was found to be inducible by systemic administration of medroxyprogesterone acetate (MPA). MPA, when used in a mixture with testosterone and/or 4-androstenedione in vitro, acted as a competitive inhibitor of the reduction of these substrates. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00220345
- Volume :
- 57
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Dental Research
- Publication Type :
- Academic Journal
- Accession number :
- 36572530
- Full Text :
- https://doi.org/10.1177/00220345780570032001