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Statistical Issues for Combining Multiple Caries Diagnostics for Demonstrating Caries Efficacy.
- Source :
- Journal of Dental Research; Jul2004 Supplement 1, pC109-C112, 4p, 3 Charts
- Publication Year :
- 2004
-
Abstract
- Caries efficacy in clinical trials has been based primarily on visual examinations supplemented by Fiber Optic Transillumination (FOTI) and radiography, with the assessments combined at the surface level to classify each surface as to its caries status. Newer caries diagnostics techniques measure the caries process in a quantitative manner and so thus yield continuous rather than ordinal results. The objective of this study was to examine various methods for the analysis of multiple outcomes in clinical trials and to compare their usefulness for the analysis of caries trials. Four global tests (rank sum, ordinary least squares, general least squares, and generalized estimating equations) and two caries indices (based on average and maximum values of the methods) were evaluated with the use of one-year follow-up data from 1063 children in a recent caries trial. A new hybrid method was also developed and evaluated. All of the methods performed well when the diagnostic measures showed product differences in caries in the same direction. Ease of use, interpretability, and distributional assumptions must be considered before a consensus method for analysis of multiple diagnostic measures in caries trials can be determined. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00220345
- Database :
- Complementary Index
- Journal :
- Journal of Dental Research
- Publication Type :
- Academic Journal
- Accession number :
- 36470134
- Full Text :
- https://doi.org/10.1177/154405910408301s22