Back to Search
Start Over
Performance and thermoregulatory effects of chronic bupropion administration in the heat.
- Source :
- European Journal of Applied Physiology; Feb2009, Vol. 105 Issue 3, p493-498, 6p, 3 Graphs
- Publication Year :
- 2009
-
Abstract
- <bold>Unlabelled: </bold>The combination of acute dopamine/noradrenaline reuptake inhibition (bupropion; BUP) and heat stress (30 degrees C) significantly improves performance (9%). Furthermore the maintenance of a higher power output resulted in the attainment of significantly higher heart rates and rectal temperatures--above 40 degrees C--in the BUP trial compared to the placebo trial. Since BUP is an aid to cease smoking that is taken for longer periods, question remains if similar performance and thermoregulatory effects are found following administration of BUP over several days (10 days). The purpose of the present study was to examine the effects of chronic BUP on exercise performance, thermoregulation and hormonal variables in the heat. Eight trained male cyclists participated in the study. Subjects completed two trials consisting of 60 min fixed intensity exercise (55% W (max)) followed by a time trial (TT) in a double-blind randomized crossover design. Exercise was performed in 30 degrees C. Subjects took either placebo (PLAC) or BUP (Zyban) for 3 days (150 mg), followed by 300 mg for 7 days. Chronic BUP did not influence TT performance (BUP 40'42'' +/- 4'18''; PLAC 41'36'' +/- 5'12''), but significantly increased core temperature (P = 0.030). BUP significantly increased circulating growth hormone levels (PLAC: 9.8 +/- 5.8 ng L(-1); BUP: 13 +/- 6.8 ng L(-1); P < 0.008).<bold>Discussion/conclusion: </bold>Chronic BUP did not influence TT performance in 30 degrees C and subjects did not reach core temperature values as high as observed during the acute BUP study. It seems that chronic administration results in an adaptation of central neurotransmitter homeostasis, resulting in a different response to the drug. [ABSTRACT FROM AUTHOR]
- Subjects :
- DOPAMINE
NORADRENALINE
BODY temperature regulation
PHYSIOLOGICAL effects of heat
EXERCISE
HOMEOSTASIS
PHYSIOLOGICAL adaptation
CLINICAL trials
COMPARATIVE studies
DRUG administration
EXERCISE tests
HEART beat
HEAT
RESEARCH methodology
DOPAMINE uptake inhibitors
MEDICAL cooperation
PHYSICAL fitness
RESEARCH
HEALTH self-care
SELF-evaluation
EVALUATION research
HUMAN growth hormone
BUPROPION
Subjects
Details
- Language :
- English
- ISSN :
- 14396319
- Volume :
- 105
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- European Journal of Applied Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 36164889
- Full Text :
- https://doi.org/10.1007/s00421-008-0929-x