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Evaluation of Adjuvant Doxorubicin-Based Chemotherapy for the Treatment of Feline Mammary Carcinoma.
- Source :
- Journal of Veterinary Internal Medicine; Jan2009, Vol. 23 Issue 1, p123-129, 7p, 5 Charts, 2 Graphs
- Publication Year :
- 2009
-
Abstract
- Background: Feline mammary carcinomas (FMC) are locally invasive and highly metastatic tumors. Because of the high metastatic potential, patients often are treated with adjuvant doxorubicin-based chemotherapy, but little data exist to evaluate the effect of this strategy. Hypothesis: Adjuvant doxorubicin-based chemotherapy improves outcome for FMC compared with surgery alone. Animals: Cats with naturally occurring, biopsy-confirmed FMC treated with either surgery alone (Sx) or with surgery plus adjuvant doxorubicin-based chemotherapy (Sx + Chemo). Methods: Retrospective cohort study. Clinical data were collected and compared to identify differences between groups. Outcome results were determined and compared. Prognostic factors for disease-free survival (DFS) and overall survival were evaluated. Results: Seventy-three cats were evaluated, of which 37 were in the Sx group and 36 in the Sx + Chemo group. No differences in clinical data were found between Sx and Sx + Chemo groups. Median DFS times for the Sx and Sx + Chemo groups were 372 and 676 days, respectively ( P= .15) and median survival times (ST) were 1,406 and 848 days, respectively ( P= .78). For cats that underwent a unilateral radical mastectomy, ST was significantly longer for the Sx + Chemo compared with the Sx group (1,998 versus 414 days, respectively; P= .03). Conclusions and Clinical Importance: This study did not find a benefit to adjuvant doxorubicin-based chemotherapy in cats with FMC. Additional studies are required to determine whether patient subgroups with negative prognostic factors may benefit from adjuvant chemotherapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- BREAST cancer
BONE metastasis
TUMORS
DRUG therapy
CATS
VETERINARY surgery
Subjects
Details
- Language :
- English
- ISSN :
- 08916640
- Volume :
- 23
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Veterinary Internal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 35948487
- Full Text :
- https://doi.org/10.1111/j.1939-1676.2008.0244.x