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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor.

Authors :
Coppé, Jean-Philippe
Patil, Christopher K.
Rodier, Francis
Yu Sun
Muñoz, Denise P.
Goldstein, Joshua
Nelson, Peter S.
Desprez, Pierre-Yves
Campisi, Judith
Source :
PLoS Biology; Dec2008, Vol. 6 Issue 12, pe301, 1p, 6 Color Photographs, 1 Graph
Publication Year :
2008

Abstract

By controlling how damaged cells modify their surrounding tissue environment, a tumor suppressor gene can restrain, and an oncogene can promote, the development of cancer. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15449173
Volume :
6
Issue :
12
Database :
Complementary Index
Journal :
PLoS Biology
Publication Type :
Academic Journal
Accession number :
35907720
Full Text :
https://doi.org/10.1371/journal.pbio.0060301