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Catalyst-Free, Rapid Synthesis of Fused Bicyclic Thiazolo-Pyrimidine and Pyrimido-Thiazine Derivatives by a Microwave-Assisted Method.
- Source :
- Phosphorus, Sulfur & Silicon & the Related Elements; Jan2009, Vol. 184 Issue 1, p34-44, 11p, 2 Diagrams, 2 Charts
- Publication Year :
- 2009
-
Abstract
- The present investigation deals with the rapid microwave-assisted synthesis of compounds containing fused bicyclic systems. Dihydropyrimidines obtained via a microwave-assisted Biginelli reaction were treated with dibromo alkanes under microwave conditions to yield thiazolo-pyrimidine and pyrimido-thiazine systems. The usefulness of this method lies in carrying out the reaction without a catalyst and solvent in a shorter time. The reaction was successfully extended to develop fused systems from benzimidazole-2-thiol. [ABSTRACT FROM AUTHOR]
- Subjects :
- PYRIMIDINES
THIAZINES
MICROWAVES
BICYCLIC compounds
CHEMICAL reactions
Subjects
Details
- Language :
- English
- ISSN :
- 10426507
- Volume :
- 184
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Phosphorus, Sulfur & Silicon & the Related Elements
- Publication Type :
- Academic Journal
- Accession number :
- 35809271
- Full Text :
- https://doi.org/10.1080/10426500802077564