Final Editorial for the Newcastle Editorial Team.

The article offers insights on the industrial symbiosis an the field of ecology in the U.S. It introduces regional studies to industrial symbiosis and the field of ecology to which it belongs, and then summarizes each of the papers contributing to the issue. It presents conclusions about the potential overlapping between industrial symbiosis and regional development which claims that industrial symbiosis (IS) does have potential to generate regional environmental economic benefits. Nevertheless, increasing imperatives for regional sustainable economic development may dictate that IS system-scale approach to resource efficiency receive serious exploration.