Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's diseaseElectronic supplementary information (ESI) available: experimental details of syntheses, turbidity, TEAC and MTT assays; selected crystallographic data for Hnbp, Cu(ppp)2and Cu(nbp)2. CCDC reference numbers 697416–697418. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/b815404j

Selective design modifications of specifically substituted 3-hydroxy-4(1H)-pyridinones show possibly advantageous ring freedom while maintaining metal-binding ability and antioxidant capacity, moving toward an efficient potential treatment for Alzheimer's disease. [ABSTRACT FROM AUTHOR]