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Urease loaded alginate microspheres for blood purification.
- Source :
- Journal of Microencapsulation; Dec2008, Vol. 25 Issue 8, p569-576, 8p, 2 Diagrams, 4 Graphs
- Publication Year :
- 2008
-
Abstract
- In this paper a device, based on urease-loaded microspheres, is presented. The first task of this work was the optimization of a procedure for the alginate microspheres realization, having a radius as close as possible to the optimal one necessary to achieve the maximum enzyme exploitation. This optimal radius was calculated theoretically through a mathematical model which describes the concentration of substrate (urea) inside the microspheres on the assumption of a diffusion-reaction mechanism. The enzyme-loaded microspheres were successfully tested in a prototypal device aimed at the depletion of urea from a circulating fluid simulating blood flow: the results showed that urea concentration in the circulating fluid drops down to less than 25% of the initial value after 5 h. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02652048
- Volume :
- 25
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Microencapsulation
- Publication Type :
- Academic Journal
- Accession number :
- 35163483
- Full Text :
- https://doi.org/10.1080/02652040802081227