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Comparative efficacy of maropitant and selected drugs in preventing emesis induced by centrally or peripherally acting emetogens in dogs.
- Source :
- Journal of Veterinary Pharmacology & Therapeutics; Dec2008, Vol. 31 Issue 6, p533-537, 5p, 2 Charts, 1 Graph
- Publication Year :
- 2008
-
Abstract
- Maropitant (Cerenia<superscript>™</superscript>; a novel, selective neurokinin<subscript>1</subscript> receptor antagonist), chlorpromazine, metoclopramide and ondansetron were compared in two randomized, placebo-controlled studies for efficacy in preventing emesis induced by emetogens acting centrally (apomorphine; Study 1) or peripherally (syrup of ipecac; Study 2) in dogs. In each study, ten male and ten female beagles were treated in a five-treatment, five-period crossover design. The five treatments were 0.9% saline (0.1 mL/kg), maropitant (1 mg/kg), metoclopramide (0.5 mg/kg), or chlorpromazine (0.5 mg/kg) all administered subcutaneously, or ondansetron (0.5 mg/kg) administered intravenously. One hour posttreatment dogs were challenged with apomorphine at 0.1 mg/kg intravenously (Study 1) or syrup of ipecac at 0.5 mL/kg orally (Study 2). Following emetogen challenge, dogs were observed for 30 min (Study 1) or 1 h (Study 2) for emesis. No clinical signs, other than those related to emesis, were observed. Efficacy of maropitant in preventing emesis induced centrally by apomorphine was not different ( P > 0.05) from metoclopramide or chlorpromazine but was superior ( P < 0.0001) to ondansetron. Efficacy of maropitant in preventing emesis induced by syrup of ipecac was not different ( P > 0.05) from ondansetron but was superior ( P ≤ 0.0102) to metoclopramide or chlorpromazine. Maropitant was effective ( P < 0.0001 relative to control) in preventing vomiting caused by stimulation of either central or peripheral emetic pathways, whereas the other drugs examined prevented vomiting caused by central (metoclopramide and chlorpromazine; P < 0.0001) or peripheral (ondansetron; P < 0.0001) stimulation but not both. [ABSTRACT FROM AUTHOR]
- Subjects :
- VOMITING treatment
LABORATORY dogs
CHLORPROMAZINE
PLACEBOS
APOMORPHINE
Subjects
Details
- Language :
- English
- ISSN :
- 01407783
- Volume :
- 31
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Veterinary Pharmacology & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 35162821
- Full Text :
- https://doi.org/10.1111/j.1365-2885.2008.00991.x