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Outcomes in the use of intra-tympanic gentamicin in the treatment of Ménière's diseaseThis paper was previously presented at the Australasian Society of Otolaryngology and Head and Neck Surgery National Conference, May 2003, Cairns, Queensland, Australia.
- Source :
- Journal of Laryngology & Otology; Feb2006, Vol. 120 Issue 2, p98-102, 5p
- Publication Year :
- 2006
-
Abstract
- The pathogenesis of Ménière's disease is associated with a disorder of ionic homeostasis, with the pathologic correlate being endolymphatic hydrops. Despite uncertainty as to its particular mode of action, it is accepted wisdom that intra-tympanic gentamicin has a definite therapeutic role in the control of symptoms in patients who fail to respond to medical therapy. This study reports an evaluation of the efficacy of intra-tympanic gentamicin in the treatment of Ménière's disease and also presents a simple, reliable, safe method of administering gentamicin for this purpose.A retrospective review of 56 patients undergoing intra-tympanic gentamicin treatment for Ménière's disease was conducted. Response to treatment was analysed using a patient survey and examination of pure-tone averages. An overall significant improvement in vertigo symptoms of 81.3 per cent was found. There was a 21.4 per cent rate of significant hearing loss, defined as greater than 10 dB, with an average loss in this group of 18.5 dB. A single dose of gentamicin applied directly to the round window resulted in a high rate of control of vertigo, with acceptably low rates of hearing loss. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00222151
- Volume :
- 120
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Laryngology & Otology
- Publication Type :
- Academic Journal
- Accession number :
- 34953837
- Full Text :
- https://doi.org/10.1017/S002221510500188X