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Direct-Current Electrical Field Guides Neuronal Stem/Progenitor Cell Migration.
- Source :
- Stem Cells; Aug2008, Vol. 26 Issue 8, p2193-2200, 8p, 1 Color Photograph, 5 Graphs
- Publication Year :
- 2008
-
Abstract
- Direct-current electrical fields (EFs) promote nerve growth and axon regeneration. We report here that at physiological strengths, EFs guide the migration of neuronal stem/progenitor cells (NSPCs) toward the cathode. EF-directed NSPC migration requires activation of Nmethyl- D-aspartate receptors (NMDARs), which leads to an increased physical association of Rho GTPase Rac1- associated signals to the membrane NMDARs and the intracellular actin cytoskeleton. Thus, this study identifies the EF as a directional guidance cue in controlling NSPC migration and reveals a role of the NMDAR/Rac1/actin signal transduction pathway in mediating EF-induced NSPC migration. These results suggest that as a safe physical approach in clinical application, EFs may be developed as a practical therapeutic strategy for brain repair by directing NSPC migration to the injured brain regions to replace cell loss. [ABSTRACT FROM AUTHOR]
- Subjects :
- ELECTRIC fields
NEURAL stem cells
RHO GTPases
G proteins
CELL migration
ACTIN
Subjects
Details
- Language :
- English
- ISSN :
- 10665099
- Volume :
- 26
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Stem Cells
- Publication Type :
- Academic Journal
- Accession number :
- 34780645
- Full Text :
- https://doi.org/10.1634/stemcells.2007-1022