Association of a Single-Nucleotide Polymorphism in the Pregnane X Receptor (PXR 63396CrT) with Reduced Concentrations of Unboosted Atazanavir.

This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T→C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P=.008) and 5.13 (P=.02). Prospective studies determining potential clinical usefulness are now warranted. [ABSTRACT FROM AUTHOR]