Regulation of chromatin structure by site-specific histone H3 methyltransferases.

Authors :: Rea, Stephen
Eisenhaber, Frank
O'Carroll, Donal
Strahl, Brian D.
Zu-Wen Sun
Schmid, Manfred
Opravil, Susanne
Mechtler, Karl
Ponting, Chris P.
Allis, C. David
Jenuwein, Thomas
Source :: Nature; 8/10/2000, Vol. 406 Issue 6796, p593, 7p, 2 Color Photographs, 6 Diagrams, 7 Graphs
Publication Year :: 2000
Abstract: Presents a study which shows that human SUV39H1 and murine Suv39h1 encode histone H3-specific methyltransferases that selectively methylate lysine 9 of the amino terminus of histone H3 in vitro. Data, which reveals a functional interdependence of site-specific H3 tail modifications; Suggestion in the data of a dynamic mechanism for the regulation of higher-order chromatin.

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