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Characterization of sub-systems of a molecular biowire-based biosensor device.
- Source :
- Microchimica Acta; Sep2008, Vol. 163 Issue 1/2, p49-56, 8p, 2 Black and White Photographs, 3 Diagrams, 1 Chart, 6 Graphs
- Publication Year :
- 2008
-
Abstract
- We describe the fabrication and characterization of components of a biosensor system that can be used for simultaneous screening of multiple pathogens in a sample. The two sub-systems are: (1) a mixed antibody immunosensor based on molecular biowires and (2) a multi-channel potentiostat for measuring conductance across the immunosensor. The immunosensor operates by converting binding events between antigen and antibody into a measurable electrical signal using polyaniline nanowires as labels and transducers. By mixing and patterning antibodies on a substrate, the response of the biosensor can detect the presence of either one of several pathogens present in the analyte through an equivalent change in conductance. The paper also presents a 42-channel potentiostat array which can be used for measuring the conductance change across the immunosensor. Each channel of the array uses a novel semi-synchronous ΣΔ modulator which enables detection down to femtoampere current ranges. [ABSTRACT FROM AUTHOR]
- Subjects :
- BIOSENSORS
POTENTIOSTAT
ELECTROCHEMICAL apparatus
TRANSDUCERS
POTENTIOMETERS
Subjects
Details
- Language :
- English
- ISSN :
- 00263672
- Volume :
- 163
- Issue :
- 1/2
- Database :
- Complementary Index
- Journal :
- Microchimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 34178737
- Full Text :
- https://doi.org/10.1007/s00604-008-0950-0