Lung inflammation and thrombogenic responses in a time course study of Csb mice exposed to ozone.

The article evaluates the time-course events after a single ozone exposure in transcription-coupled repair defective Csb and wild type mice. It is said that the mice were exposed for 3h to 2 ppm ozone. Biological parameters related to oxidative stress and inflammation were examined in the lungs at 0, 4, 9, 24 and 48 h after exposure. It is said that the study revealed a significant biological response to ozone, for both Csb and wild type mice. It is inferred that the experiments have shown that ozone induces not only inflammation but also procoagulant reactions in the lungs of mice. Furthermore, it is said that the results have implications for understanding the systemic effects induced by oxidant air pollutants.