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Urea Cycle Disorders.
- Source :
- Pediatric Neuropathology; 2007, p179-185, 7p
- Publication Year :
- 2007
-
Abstract
- In the urea cycle, six enzymes are required to convert ammonia to urea: N-acetylglutamate synthetase (NAGS), carbamoylphosphate synthetase (CPS), ornithine transcarbamylase (OTC), argininosuccinate synthetase (ASS), argininosuccinate lyase, and arginase. Deficiency of any of these enzymes may cause disease. Such infants are asymptomatic for 1-5 days but then feed poorly, vomit, and become lethargic. They may be irritable, rigid, and convulse. They exhibit hyperpnea and respiratory alkalosis, hepatomegaly, and jaundice; and they may have brain edema with bulging fontanels. Death ensues without treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISBNs :
- 9784431702467
- Database :
- Complementary Index
- Journal :
- Pediatric Neuropathology
- Publication Type :
- Book
- Accession number :
- 33755504
- Full Text :
- https://doi.org/10.1007/978-4-431-49898-8_12