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Craniospinal Radiotherapy in Adult Medulloblastoma.

Craniospinal Radiotherapy in Adult Medulloblastoma.

Authors :
Faruk Zorlu
Pervin Hurmuz
Mustafa Cengiz
Alev Turker
Figen Soylemezoglu
Murat Gurkaynak
Source :
Strahlentherapie und Onkologie; May2007, Vol. 183 Issue 5, p236-240, 5p
Publication Year :
2007

Abstract

Purpose:  To evaluate the outcome and prognostic factors of adult patients with medulloblastoma. Patients and Methods:  26 adult medulloblastoma patients with a median age of 27 were subjected to craniospinal radiotherapy. A dose of 30.6 Gy with 1.8 Gy/fraction/day was prescribed to M0 patients, while 36 Gy were to be applied in patients with positive cerebrospinal liquor findings. The posterior fossa was boosted to 54 Gy. While 20 patients underwent external-beam radiotheray alone, only six received sequential adjuvant chemotherapy. Results:  Male/female ratio was 1.2. Preradiotherapy Karnofsky performance status was recorded as median 100%. 50% were classified as poor risk (n = 10, subtotal resection; n = 3, M+). The median follow-up time was 46.5 months. The 5-year actuarial survival rates for recurrence-free, distant metastasis-free, disease-free, and overall survival were 82.5%, 90.8%, 73.5%, and 89.7%, respectively. Patient characteristics, treatment factors and tumor characteristics failed to show any significance in univariate analysis. Grade 3 or 4 late morbidities were not observed. Conclusion:  Yet, the current standard of care seems to remain craniospinal irradiation after maximal surgical resection of the primary neoplasm without clear indications for adjuvant chemotherapy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01797158
Volume :
183
Issue :
5
Database :
Complementary Index
Journal :
Strahlentherapie und Onkologie
Publication Type :
Academic Journal
Accession number :
33448395