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A new hTopo I isomerase inhibitor produced by a mangrove endophytic fungus no. 2240.
- Source :
- Journal of Asian Natural Products Research; Jul2008, Vol. 10 Issue 7, p607-610, 4p, 1 Black and White Photograph, 3 Diagrams, 2 Charts
- Publication Year :
- 2008
-
Abstract
- A new hTopo I isomerase inhibitor, (+)-3,3',7,7',8,8'-hexahydroxy-5,5'-dimethylbianthraquinone (2240A), was isolated from the mangrove endophytic fungus no. 2240 collected from an estuarine mangrove at the South China Sea coast. Its structure was elucidated by spectral analyses including two-dimensional NMR, HR-EI-MS, IR, and UV. The hTopo I isomerase inhibition experiment showed that 2240A (1) possessed strong inhibiting activity. When its inhibition concentration was 4.65 μmol/l, its percent inhibition rate was 59.1%, while the lowest inhibition concentration of the positive control camptothecin was 1.00 × 103 μmol/l. [ABSTRACT FROM AUTHOR]
- Subjects :
- ISOMERASES
MANGROVE plants
ENDOPHYTIC fungi
CHEMICAL inhibitors
CAMPTOTHECIN
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 10
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 33193501
- Full Text :
- https://doi.org/10.1080/10286020802133167