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A Reproduction of Inflow Restriction in the Mock Circulatory System to Evaluate a Hydrodynamic Performance of a Ventricular Assist Device in Practical Conditions.
- Source :
- Life System Modeling & Simulation; 2007, p553-558, 6p
- Publication Year :
- 2007
-
Abstract
- A novel in vitro mock circulatory system, which enables to reproduce an inflow restriction, simulating blood volume pooling due to heart failure, was developed to evaluate a hydrodynamic performance of a pulsatile ventricular assist device (VAD) in practical conditions. The concept of this development was motivated by a difference of an inflow restriction between in vitro and in vivo environments. The major idea of this study is to reproduce an inflow restriction by using a centrifugal pump placed at an inflow side of a left ventricular model instead of a constant head reservoir in a conventional circuit. In the novel circuit, the maximum flow rate was obtained at lower systolic fraction as compared with a conventional circuit. This similar tendency by the novel one was observed in an acute animal experiment in sheep. This result suggests that a new mock circuit is effective to confirm a practical drive strategy of the VAD for various diseased conditions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISBNs :
- 9783540747703
- Database :
- Complementary Index
- Journal :
- Life System Modeling & Simulation
- Publication Type :
- Book
- Accession number :
- 33169854
- Full Text :
- https://doi.org/10.1007/978-3-540-74771-0_63