Minimization of potential hERG liability in histamine H3 receptor antagonists.

The article presents a research study on the medical chemistry strategy that produced histamine H₃ selectivity relative to the hERG potassium channel involved in cardiac repolarization. It describes the assessment of pharmacokinetic profiles of the male rats. It states that the polarity in form of heterocycles were able to minimize hERG interaction while preserving behavioral efficacy.