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Aqueous/organic cross coupling: Sustainable protocol for Sonogashira reactions of heterocycles.
- Source :
- Green Chemistry; May2008, Vol. 10 Issue 5, p563-570, 8p
- Publication Year :
- 2008
-
Abstract
- The water soluble Pd complex of dicyclohexyl(2-sulfo-9-(3-(4-sulfophenyl)propyl)-9H-fluoren-9-yl)phosphine was used for an efficient copper free and sustainable reaction protocol for Sonogashira cross couplings. Using a water/ipropanol mixture as the solvent and K2CO3 as base, numerous heterocyclic and aryl bromides and chlorides were reacted with various acetylenes in near quantitative yield at 1 mol% catalyst loading and 90 °C. [ABSTRACT FROM AUTHOR]
- Subjects :
- HETEROCYCLIC compounds
COPPER
CATALYSTS
SOLVENTS
Subjects
Details
- Language :
- English
- ISSN :
- 14639262
- Volume :
- 10
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Green Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32932573