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Accurate determination of half-life and radionuclidic purity of reactor produced 177gLu (177mLu) for metabolic radiotherapy.
- Source :
- Journal of Radioanalytical & Nuclear Chemistry; Jun2008, Vol. 276 Issue 3, p813-818, 6p, 2 Charts, 6 Graphs
- Publication Year :
- 2008
-
Abstract
- Thanks to its favorable decay characteristics, <superscript>177g</superscript>Lu is finding several applications in nuclear medicine, especially for palliative metabolic radiotherapy of cancer and radioimunotherapy. <superscript>177g</superscript>Lu is produced in thermal nuclear reactor either by direct neutron capture <superscript>176</superscript>Lu(n,γ)<superscript>177(m+g)</superscript>Lu on either natural or enriched <superscript>176</superscript>Lu target, or by reaction on enriched <superscript>176</superscript>Yb target followed by negatron decay. The latter method does produce a high radionuclidic purity and high specific activity radionuclide in no-carrier-added form, since <superscript>177</superscript>Yb decays solely to the ground state <superscript>177g</superscript>Lu. Conversely, the first method does produce a low specific activity <superscript>177g</superscript>Lu in carrier-added form,<superscript>1</superscript> contaminated by the long-lived radioisotopic impurity <superscript>177m</superscript>Lu. The accurate determination of radionuclidic purity and half-life of <superscript>177g</superscript>Lu carried out by HPGe and LSCS is presented in some details. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02365731
- Volume :
- 276
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Radioanalytical & Nuclear Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32672767
- Full Text :
- https://doi.org/10.1007/s10967-008-0637-3