Musculoskeletal measurement tools from the International Prophylaxis Study Group (IPSG).

The article reports on the findings from long-term observational studies concerning the randomized controlled trial of primary prophylaxis versus on-demand therapy for young boys with severe haemophilia A. It provides solid evidence in support of regular replacement therapy with the aim of preventing recurrent joint bleeding. Meanwhile, the International Prophylaxis Study Group (IPSG) focuses on the outcome measures related to the early detection and quantification of joint disease.