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INFLUENCE OF MATRIX-SUSPENDED DEMINERALIZED BONE ON OSSEOUS REPAIR USING A CRITICAL-SIZED DEFECT IN THE RAT (RATTUS NORVEGICUS) CALVARIUM.
- Source :
- Journal of Oral Implantology; 2008, Vol. 34 Issue 2, p83-89, 7p, 1 Color Photograph, 1 Black and White Photograph, 2 Charts
- Publication Year :
- 2008
-
Abstract
- Demineralized freeze-dried bone (DFDB) in matrix form must be rehydrated with a carrier medium which allows for easy manipulation during periodontal surgery. The purpose of this study was to evaluate how human DFDB suspended in a polyol matrix affects new bone formation in the rat calvarium critical-sized defect (CSD)model. Fifty-five adult male Harlan Sprague-Dawley rats were assigned to 1 of 5 treatment groups: polyol, 100% DFDB, 47% DFDB/polyol, 47% DFDB, or an unfilled control. They were then placed into 8-m calvarial CSDs. The bone donor source company for the DFDB and DFDB/polyol groups was the same. Calvaria were harvested 10 weeks after surgery and evaluated histomorphometrically. The diameter of bone particles from the 3 groups containing DFDB was measured by scanning electron microscopy. There was no statistically significant difference in the percentage of bone fill between any of the groups, although the 100% DFDB group exhibited the most bone fill. The 47% DFDB/polyol and 47% DFDB groups had similar amounts of bone formation. The average size of the demineralized bone particles from the 100% DFDB group was significantly smaller than that of the other 2 groups containing DFDB. Adding a polyol to DFDB produced similar osseous regeneration in the rat calvarium defect model vs DFDB alone. Yet from a clinical standpoint, the polyol enhanced graft handling and stability. Graft particle size may have an effect on bone fill. [ABSTRACT FROM AUTHOR]
- Subjects :
- BONE cells
CALVARIA
POLYOLS
GINGIVA surgery
BONE growth
LABORATORY rats
Subjects
Details
- Language :
- English
- ISSN :
- 01606972
- Volume :
- 34
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Oral Implantology
- Publication Type :
- Academic Journal
- Accession number :
- 31805734
- Full Text :
- https://doi.org/10.1563/1548-1336(2008)34[83:IOMDBO]2.0.CO;2