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Simultaneous PET-MRI: a new approach for functional and morphological imaging.
- Source :
- Nature Medicine; Apr2008, Vol. 14 Issue 4, p459-465, 7p, 1 Diagram, 3 Graphs
- Publication Year :
- 2008
-
Abstract
- Noninvasive imaging at the molecular level is an emerging field in biomedical research. This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography (PET) and magnetic resonance imaging (MRI). Although the value of PET lies in its high-sensitivity tracking of biomarkers in vivo, it lacks resolving morphology. MRI has lower sensitivity, but produces high soft-tissue contrast and provides spectroscopic information and functional MRI (fMRI). We have developed a three-dimensional animal PET scanner that is built into a 7-T MRI. Our evaluations show that both modalities preserve their functionality, even when operated isochronously. With this combined imaging system, we simultaneously acquired functional and morphological PET-MRI data from living mice. PET-MRI provides a powerful tool for studying biology and pathology in preclinical research and has great potential for clinical applications. Combining fMRI and spectroscopy with PET paves the way for a new perspective in molecular imaging. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10788956
- Volume :
- 14
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Nature Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31546575
- Full Text :
- https://doi.org/10.1038/nm1700