Simultaneous Derivative and Multi-Component Spectrophotometric Determination of Drotaverine Hydrochloride and Mefenamic Acid in Tablets.

Two new, simple, accurate and economical spectrophotometric methods have been developed for simultaneous estimation of drotaverine hydrochloride and mefenamic acid in two-component tablet formulation. The methods employed are, first derivative spectrophotometry, using zero crossing technique and multicomponent analysis. Both the drugs obey the Beer's law in the concentration range employed for these methods. The results of analysis are validated by statistical evaluation and recovery studies. [ABSTRACT FROM AUTHOR]