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Neurodevelopmental outcome in prenatally diagnosed isolated agenesis of the corpus callosum.

Authors :
Chadie, A.
Radi, S.
Trestard, L.
Charollais, A.
Eurin, D.
Verspyck, E.
Marret, S.
Source :
Acta Paediatrica; Apr2008, Vol. 97 Issue 4, p420-424, 5p, 1 Diagram
Publication Year :
2008

Abstract

Aim: To evaluate long-term neurodevelopmental outcomes in children with prenatally diagnosed, isolated agenesis of the corpus callosum (ACC). Methods: We retrospectively reviewed data for 20 children born between January 1991 and November 2003 in the Haute-Normandie region of France with a prenatal diagnosis of isolated ACC. We collected data on pre-and postnatal neuroimaging findings, clinical features at birth and neurodevelopmental outcomes. Results: Follow-up ranged from 3 to 16 years. ACC was complete in 11 patients (55%), partial in 2 (10%), hypoplastic in 3 (15%) and associated with an interhemispheric cyst in 4 (20%). Neurodevelopmental outcome was normal in 11 (55%) patients, including 8 with complete ACC; moderate disability was present in 5 (25%) patients and severe disability in 4 (20%) patients. In 3 of the 4 patients with severe disability, postnatal cerebral magnetic resonance imaging (MRI) showed additional major cerebral abnormalities. Conclusion: Neurodevelopmental outcome was good in most of our patients with isolated ACC, with 80% of patients having normal outcomes or moderate disabilities. A prenatal diagnosis of isolated ACC may not warrant termination of pregnancy. A carefully interpreted prenatal cerebral MRI is crucial to detect associated cerebral abnormalities; a longer follow-up is necessary to look for moderate disabilities. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08035253
Volume :
97
Issue :
4
Database :
Complementary Index
Journal :
Acta Paediatrica
Publication Type :
Academic Journal
Accession number :
31336283
Full Text :
https://doi.org/10.1111/j.1651-2227.2008.00688.x