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Synthesis of mangiferin derivatives as protein tyrosine phosphatase 1B inhibitors.
- Source :
- Chemistry of Natural Compounds; Nov2007, Vol. 43 Issue 6, p663-666, 4p, 1 Chart
- Publication Year :
- 2007
-
Abstract
- Protein tyrosine phosphatase 1B (PTP1B) has received much attention due to its pivotal role in type 2 diabetes and obesity as a negative regulator of the insulin signaling pathway. Mangiferin, a xanthone glucoside, has been reported to possess significant antidiabetic activity. In the present study, a series of mangiferin derivatives was synthesized and evaluated for their PTP1B inhibitory activity. Some of the screened compounds displayed good PTP1B inhibitory activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROTEIN-tyrosine phosphatase
GLUCOSIDES
PHOSPHATASES
TYPE 2 diabetes
OBESITY
Subjects
Details
- Language :
- English
- ISSN :
- 00093130
- Volume :
- 43
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Chemistry of Natural Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 30048213
- Full Text :
- https://doi.org/10.1007/s10600-007-0223-x