Back to Search
Start Over
Apolipoprotein E and cognitive performance.
- Source :
- Nature; 3/23/2000, Vol. 404 Issue 6776, p352, 3p, 4 Graphs
- Publication Year :
- 2000
-
Abstract
- Investigates the spatial memory of transgenic mice carrying different isoforms of apolipoprotein E (apoE), key proteins implicated in the development of Alzheimer's disease. Susceptibility of female mice to apoE4-induced deficits; Differential effects of apoE isoforms on cognitive impairment; Intracellular accumulation of beta-amyloid or diffusible extracellular forms of the protein.
- Subjects :
- APOLIPOPROTEIN E
ALZHEIMER'S disease
SPATIAL ability
ANIMAL models in research
Subjects
Details
- Language :
- English
- ISSN :
- 00280836
- Volume :
- 404
- Issue :
- 6776
- Database :
- Complementary Index
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 2982387
- Full Text :
- https://doi.org/10.1038/35006165