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Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell.
- Source :
- Leukemia (08876924); Feb2008, Vol. 22 Issue 2, p400-405, 6p, 1 Color Photograph, 1 Diagram
- Publication Year :
- 2008
-
Abstract
- To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) subtype of DLBCL. [ABSTRACT FROM AUTHOR]
- Subjects :
- GENE expression
GENETIC regulation
LYMPHOPROLIFERATIVE disorders
CENTRAL nervous system
LYMPH nodes
B cells
B cell lymphoma
CENTRAL nervous system tumors
COMPARATIVE studies
IMMUNE response
IMMUNOCOMPETENT cells
LYMPHOID tissue
LYMPHOMAS
RESEARCH methodology
MEDICAL cooperation
RESEARCH
RESEARCH funding
EVALUATION research
MICROARRAY technology
GENE expression profiling
Subjects
Details
- Language :
- English
- ISSN :
- 08876924
- Volume :
- 22
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Leukemia (08876924)
- Publication Type :
- Academic Journal
- Accession number :
- 29387994
- Full Text :
- https://doi.org/10.1038/sj.leu.2405019