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Anti-inflammatory effect of α, β-Amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis.
- Source :
- Inflammopharmacology; Feb2008, Vol. 16 Issue 1, p48-52, 5p, 1 Diagram, 3 Graphs
- Publication Year :
- 2008
-
Abstract
- This study was aimed to evaluate the anti-inflammatory potential of triterpene α, β-amyrin in rats on acute phase periodontitis. Periodontitis was induced by ligature placement around the maxillary right second molar tooth. Rats ( n = 8/group) were pretreated with α, β-amyrin (5 and 10 mg/kg, p. o.), two hours before the induction of periodontal inflammation. Sham-operated and positive controls (lumiracoxib and dexamethasone) were included. Six hours later, plasma levels of TNF-alpha were analysed. Rats were sacrificed at 24 h, and the gingival tissue analysed for myeloperoxidase (MPO) and thiobarbituric acid-reactive substances (TBARS), as measures of neutrophil influx and lipid-peroxidation, respectively α, β-Amyrin as well as dexamethasone significantly inhibited the periodontitis-associated increases of TNF-alpha, and the gingival MPO and TBARS. α, β-Amyrin effect was more prominent at 5 mg/kg. Lumiracoxib manifested varied influence on the studied parameters. These results provide evidence to show that α, β-Amyrin retards acute inflammation in rat model of periodontitis and warrant further study on its efficacy to prevent chronic periodontitis-associated bone loss. [ABSTRACT FROM AUTHOR]
- Subjects :
- PERIODONTITIS
PEROXIDATION
PERIODONTAL disease
PATHOLOGY
INFLAMMATION
RATS
Subjects
Details
- Language :
- English
- ISSN :
- 09254692
- Volume :
- 16
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Inflammopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 28838689
- Full Text :
- https://doi.org/10.1007/s10787-007-1609-x