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Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
- Source :
- Nature Genetics; Jan2008, Vol. 40 Issue 1, p29-31, 3p, 1 Chart, 1 Graph
- Publication Year :
- 2008
-
Abstract
- We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 × 10<superscript>−8</superscript> in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18–1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10614036
- Volume :
- 40
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Nature Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 28018387
- Full Text :
- https://doi.org/10.1038/ng.2007.52