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Insight into the inflammasome and caspase-activating mechanisms.
- Source :
- Expert Review of Clinical Immunology; Jan2008, Vol. 4 Issue 1, p61-77, 17p, 3 Diagrams, 2 Charts
- Publication Year :
- 2008
-
Abstract
- Inflammasomes are recently discovered molecular complexes that can sense danger signals and specifically activate caspase-1 and -5 and proinflammatory cytokines (IL-1β and IL-18). Upon signaling, the inflammasome complex forms around a NOD-like receptor family member that serves both as a danger sensor and as a recruiting platform. The number of known triggers that stimulate inflammasomes is rapidly rising, ranging from genetic mutations to microbial products, gout crystals, ultraviolet light and adjuvant chemicals. As a result of this surprising diversity, the inflammasome may have a significant impact on most medical fields. A good understanding of the molecular mechanisms underlying its activation/regulation is essential today, as several therapeutic and diagnostic tools have already reached the bedside, and more are sure to come. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1744666X
- Volume :
- 4
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Expert Review of Clinical Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 27894754
- Full Text :
- https://doi.org/10.1586/1744666X.4.1.61