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Treatment With Anti-γ-Glutamyl Transpeptidase Antibody Attenuates Osteolysis in Collagen-Induced Arthritis Mice.
- Source :
- Journal of Bone & Mineral Research; Dec2007, Vol. 22 Issue 12, p1933-1942, 10p, 1 Chart, 7 Graphs
- Publication Year :
- 2007
-
Abstract
- The article presents medical research that found therapy with anti-γ-glutamyl transpeptidase antibody attenuates osteolysis in mice with collagen-induced arthritis. γ-glutamyl transpeptidase (GGT) functions as a bone-resorbtion factor that stimulates the formation of osteoclasts. Immunohistochemistry and real time polymerase chain reaction (RT-PCR) were used to determine GGT expression.
Details
- Language :
- English
- ISSN :
- 08840431
- Volume :
- 22
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Journal of Bone & Mineral Research
- Publication Type :
- Academic Journal
- Accession number :
- 27796999
- Full Text :
- https://doi.org/10.1359/JBMR.070726