Management of hepatitis C: the potential benefits of exercise.

Hepatitis C infection occurs after viral exposure mainly through percutaneous means, with a world-wide prevalence of 1%. Of those infected, 50–80% progress to chronic hepatitis C, which is associated with hepatic and extra-hepatic signs and symptoms, the most serious being life-threatening liver cirrhosis and carcinoma. However, for many sufferers, it is the constellation of extra-hepatic signs and symptoms that has the most immediate impact on well-being and daily life. Significant positive associations have been found between hepatitis C virus (HCV) positivity and fatigue and musculoskeletal pain, both of which contribute to the general debility and impaired physical function associated with hepatitis C. Exercise is proposed to improve cardiovascular function, musculoskeletal fitness, reduce pain and disability, thereby leading to better health status and quality of life. The purpose of this review is to consider the effects of chronic hepatitis C infection on physical ability, and to present an argument for the inclusion of physiotherapist prescribed exercise as part of its management. [ABSTRACT FROM AUTHOR]