PI-6.

Aim: To observe the cruor time window of Hydroxysafflor yellow A of the mice in vivo.Methods: 70 male mice were divided into 7 groups, with the dose of 5 mg/kg, the drug was administrated ip to the mice once a day, continuously for 3-days. After the last administration for 1h, 2h, 4h, 8h, 16h, 24h, the cruor time were observed.Results: The measured cruor time was markedly longer after the last administration in the 1h, 2h, 4h, 8h and 16h groups than control group (respectively 136.8±29.5 sec in 1h group and 97.6±24.3 sec in 16h group vs 65.2±22.9 sec of control), and the 24h group had no significant change.Conclusions: The results showed that the treatment time window of Hydroxysafflor yellow A on cruor time of the mice in vivo may be continued to 16 hours after administration.Clinical Pharmacology & Therapeutics (2005) 79, P8–P8; doi: 10.1016/j.clpt.2005.12.027 [ABSTRACT FROM AUTHOR]