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Trypanosoma cruzi Infection Beats the B-cell Compartment Favouring Parasite Establishment: Can we Strike First?
- Source :
- Scandinavian Journal of Immunology; Aug/Sep2007, Vol. 66 Issue 2/3, p137-142, 6p, 2 Diagrams
- Publication Year :
- 2007
-
Abstract
- Trypanosoma cruzi, the causative agent of Chagas’ disease, may sabotage humoral response by affecting B cells at the different stages of its development. The present review highlights the contributions of our laboratory in understanding how T. cruzi hinders B-cell generation and B-cell expansion limiting host defence and favouring its chronic establishment. We discuss how homoeostatic mechanisms can be triggered to control exacerbated B-cell proliferation that favour T. cruzi infection by eliminating parasite-specific B cells. Specific targeting of evasion mechanisms displayed in T. cruzi infection, as in vivo Fas/FasL blockade or Gal-3 expression inhibition, allowed us to modulate B-cell responses enhancing the anti-parasite humoral immune response. A comprehensive understanding of the biology of the B cell in health and disease is strictly required to devise immunointervention strategies aimed at enhancing protective immune responses during infections. [ABSTRACT FROM AUTHOR]
- Subjects :
- TRYPANOSOMA cruzi
CELL proliferation
B cells
IMMUNE response
IMMUNOLOGY
HOMEOSTASIS
Subjects
Details
- Language :
- English
- ISSN :
- 03009475
- Volume :
- 66
- Issue :
- 2/3
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 25764885
- Full Text :
- https://doi.org/10.1111/j.1365-3083.2007.01968.x