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Clinical efficacy of citalopram alone or augmented with bupropion in methadone-stabilized patients.
- Source :
- American Journal on Addictions; May2007, Vol. 16 Issue 3, p187-194, 8p, 2 Charts, 4 Graphs
- Publication Year :
- 2007
-
Abstract
- Despite the success of opiate-agonist therapies such as methadone for the treatment of opiate addiction, treatment response is not complete. This study evaluates the efficacy of citalopram augmented with bupropion in the treatment of illicit opiate use in a methadone-stabilized population. We conducted a 12-week randomized, double-blind, outpatient clinical trial in which 60 subjects were randomized into one of three treatment groups: placebo, citalopram (40 mg/day) plus placebo, or citalopram (40 mg/day) plus bupropion (50 mg/day). The results indicate that neither citalopram nor citalopram augmented with bupropion were more effective than placebo in the treatment of opioid abuse. [ABSTRACT FROM AUTHOR]
- Subjects :
- OPIUM
CHEMICAL agonists
DRUG addiction
METHADONE treatment programs
PLACEBOS
THERAPEUTICS
SUBSTANCE abuse & psychology
THERAPEUTIC use of narcotics
ANALGESICS
SEROTONIN uptake inhibitors
DOPAMINE uptake inhibitors
CITALOPRAM
BUPROPION
COMBINATION drug therapy
COMPARATIVE studies
MENTAL depression
RESEARCH methodology
MEDICAL cooperation
RESEARCH
RESEARCH funding
SUBSTANCE abuse
EVALUATION research
ANXIETY disorders
RANDOMIZED controlled trials
BLIND experiment
Subjects
Details
- Language :
- English
- ISSN :
- 10550496
- Volume :
- 16
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- American Journal on Addictions
- Publication Type :
- Academic Journal
- Accession number :
- 25727968
- Full Text :
- https://doi.org/10.1080/10550490701375640