Adiponectin Gene Polymorphism (SNP276G>T) is Associated With Impaired Glucose Tolerance.

Adiponectin is fat-cell derived hormones, which is thought to be respectively protective and disadvantageous with regard to the development of cardiovascular disease (CVD) and diabetes mellitus type 2. A number of genetic variations have been studied. Among them, single nucleotide polymorphism, SNP276G>T of adiponectin gene showed an association with type 2 diabetes in different ethnic groups. The aim of the study is to examine associations between genetic variations of SNP 276 G > T with glucose tolerance status in 683 Taiwan aborigines from Southern Taiwan. Normoglycemia was classified as fasting glucose levels <110 mg/dl and hyperglycemia was ≧ 126 mg/dl. The T-allele frequencies were significantly associated with hyperglycemic state (p<0.01). After adjusting for confounding factors, waist ≧90 cm (OR=2.54, 95% CI=1.26-5.14) and SNP276 T allele carrier (OR=2.3, 95% CI=1.24-4.34) were independently associated with risks of impaired glucose tolerance status. On the other hand, adiponectin ≧ 10.9 ug/ml (OR=0.41, 95% CI=014-0.98) was negatively correlated. In conclusion, the SNP276 of the adiponectin gene and waist circumference may predict the increasing risk for impaired glucose tolerance state in general population. [ABSTRACT FROM AUTHOR]